Cosmos comments on Where's Your Sense of Mystery? - Less Wrong
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I think comparative advantage plays a role in this. If you happen to be good at numbers for whatever reason, you go into a more quantitative field, and that is how you can best contribute to the expanding frontier of knowledge.
I was very mathematically inclined from a young age, but after learning calculus I began to look elsewhere to further my knowledge. I turned towards the social sciences, which led me down a less quantitative path. I think the difference is between the study of physical systems of relatively few variables, versus complex biological systems with many interactions between many individual components. That simple mathematical precision is infeasible when dealing with complexity, it requires a different set of analytical skills and tools, which I found myself much more inclined towards.