Modafinil is probably the most popular cognitive enhancer. LessWrong seems pretty interested in it. The incredible Gwern wrote an excellent and extensive article about it.

Of all the stimulants I tried, modafinil is my favorite one. There are more powerful substances like e.g. amphetamine or methylphenidate, but modafinil has much less negative effects on physical as well as mental health and is far less addictive. All things considered, the cost-benefit-ratio of modafinil is unparalleled.

For those reasons I decided to publish my bachelor thesis on the cognitive effects of modafinil in healthy, non-sleep deprived individuals on LessWrong. Forgive me its shortcomings.

Here are some relevant quotes:

Introduction:

...the main research question of this thesis is if and to what extent modafinil has positive effects on cognitive performance (operationalized as performance improvements in a variety of cognitive tests) in healthy, non-sleep deprived individuals.... The abuse liability and adverse effects of modafinil are also discussed. A literature research of all available, randomized, placebo-controlled, double-blind studies which examined those effects was therefore conducted.

Overview of effects in healthy individuals:

...Altogether 19 randomized, double-blind, placebo-controlled studies about the effects of modafinil on cognitive functioning in healthy, non sleep-deprived individuals were reviewed. One of them (Randall et al., 2005b) was a retrospect analysis of 2 other studies (Randall et al., 2002 and 2005a), so 18 independent studies remain.
Out of the 19 studies, 14 found performance improvements in at least one of the administered cognitive tests through modafinil in healthy volunteers.
Modafinil significantly improved performance in 26 out of 102 cognitive tests, but significantly decreased performance in 3 cognitive tests.
...Several studies suggest that modafinil is only effective in subjects with lower IQ or lower baseline performance (Randall et al., 2005b; Müller et al., 2004; Finke et al., 2010). Significant differences between modafinil and placebo also often only emerge in the most difficult conditions of cognitive tests (Müller et al., 2004; Müller et al., 2012; Winder-Rhodes et al., 2010; Marchant et al., 2009).

Adverse effects:

...A study by Wong et al. (1999) of 32 healthy, male volunteers

...

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Anybody know some good Modafinil suppliers?

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Anybody know some good Modafinil suppliers?

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