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pnrjulius comments on Negative and Positive Selection - Less Wrong
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Access to labs, equipment, technicians, funding is an even greater factor. Only mathematicians can really afford to work from home. (And now, computer scientists and computational-xxx people have joined them.)
It's not quite so dire. You can't do experiments from home usually, but you can interpret experiments from home thanks to Internet publication of results. So a lot of theoretical work in almost every field can be done from outside academia.
Yes, but in most fields someone can't participate by only interpreting experiments from home. It's useful, but you can't build a career from it. Normally you really want to also be able to influence experiments in the lab to get the new data you want.