Anders Sandberg who does get the concept of sufficiently advanced technology posts saying, "Shit, turns out LTM seems to depend really heavily on whether protein blah has conformation A and B and the vitrification solution denatures it to C and it's spatially isolated so there's no way we're getting the info back, it's possible something unknown embodies redundant information but this seems really ubiquitous and basic so the default assumption is that everyone vitrified is dead". Although, hm, in this case I'd just be like, "Okay, back to chopping off the head and dropping it in a bucket of liquid nitrogen, don't use that particular vitrification solution". I can't think offhand of a simple discovery which would imply literally giving up on cryonics in the sense of "Just give up you can't figure out how to freeze people ever." I can certainly think of bad news for particular techniques, though.