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magfrump comments on [Paper] Simulation of a complete cell - Less Wrong
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I don't know if this is at all accurate, but I might expect genes to add complexity non-linearly; like each new gene gives four new possibilities, so 50 times as many genes would make the simulation up to 4^50 times as hard.
I don't think that works. It would have Mycoplasma genitalium's 525 genes making it 4^525 times as hard to simulate as water.
I agree that when I think about the number 4^525 I don't think it is reasonable for describing anything ever.