Wei_Dai comments on Self-skepticism: the first principle of rationality - Less Wrong
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Related posts: The Proper Use of Humility and How To Be More Confident... That You're Wrong.
BTW, what justifies calling self-skepticism "the first principle of rationality"? Feynman called it that, but Eliezer doesn't seem to think that self-skepticism is as important as, for example, having something to protect.