Well, cocaine is a vasoconstrictor in it's own right, that is it mediates the effect of adrenaline and the anesthetic, so you'll still have problems with end arteries. Though I guess injecting into a artery/vein, would have rather pleasant "side effects".
http://www.theverge.com/2012/8/8/3177438/cyborg-america-biohackers-grinders-body-hackers