I have had mild but long-lasting effects from revelations under the influence of MDMA and 2C-E. The revelations were personal, not about the nature of reality. I would say that they could generally be described as resulting from a reduced avoidance of thinking about things that I already had plenty of information on, and had basically positive results. Both took some time to integrate afterwards, and the 2C-E trip was at times a somewhat unpleasant look at myself. The MDMA trip was unambiguously pleasant at the time, even considering that I spent time thinking about some fairly unpleasant stuff.