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David_Gerard comments on Who Wants To Start An Important Startup? - Less Wrong
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Anecdotal evidence from female friends suggests that if you can make bra sizing not suck, you will indeed make life quite a bit better for quite a lot of people.
It seems to touch upon an incredibly raw nerve. Many of my friends are quite thoughtful and verbose people anyway, but I get the impression some of them could talk for hours about their dissatisfaction with bra sizing. If nothing else, it's given me a good heuristic for spotting potential consumer interest: follow the moaning.
You might be able to get a certain number of people to sign up just by making a credible effort to pursue a fully general solution at all. Work out ballpark figures for how much it would cost to construct a sufficiently detailed topological model, gather a starting dataset, etc., add it all up, put your proposal on Kickstarter.