If you're dealing with a person with a person with poor social skills, the onus is already on you
As a person with poor-to-middling social skills at the best of times: no, that's silly and I reject it as a working premise for conflict resolution and group interaction.
Establishing a social norm that hey, some folks here might be autistic or poorly socialized or otherwise have some difficulties with the usual set of interactions is completely different from establishing a norm that whenever someone failing at some element of socialization, and thereby causing others to feel unsafe, pressured or disturbed, then those who've had the reaction are obligated to see the situation resolved to that first party's favor.
I didn't say that. You can do what you want. But if someone made you feel uncomfortable, you already feel uncomfortable. Should they not have made you feel uncomfortable? Yes. Is it fair? No.
What are you going to do about it? That's the only question you get to answer.
One of the lessons highlighted in the thread "Less Wrong NYC: Case Study of a Successful Rationalist Chapter" is Gender ratio matters.
There have recently been a number of articles addressing one social skills issue that might be affecting this, from the perspective of a geeky/sciencefiction community with similar attributes to LessWrong, and I want to link to these, not just so the people potentially causing problems get to read them, but also so everyone else knows the resource is there and has a name for the problem, which may facilitate wider discussion and make it easier for others to know when to point towards the resources those who would benefit by them.
However before I do, in the light of RedRobot's comment in the "Of Gender and Rationality" thread, I'd like to echo a sentiment from one of the articles, that people exhibiting this behaviour may be of any gender and may victimise upon any gender. And so, while it may be correlated with a particular gender, it is the behaviour that should be focused upon, and turning this thread into bashing of one gender (or defensiveness against perceived bashing) would be unhelpful.
Ok, disclaimers out of the way, here are the links:
Some of those raise deeper issues about rape culture and audience as enabler, but the TLDR summary is:
EDITED TO ADD:
Despite the way some of the links are framed as being addressed to creepers, this post is aimed at least as much at the community as a whole, intended to trigger a discussion on how the community should best go about handling such a problem once identified, with the TLDR being "set of restraints to place on someone who is burning the commons", rather that a complete description that guarantees that anyone who doesn't meet it isn't creepy. (Thank you to jsteinhardt for clearly verbalising the misinterpretation - for discussion see his reply to this post)