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Manfred comments on What is the evidence in favor of paleo? - Less Wrong
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Interestingly, the calorie restriction effect may just be because the mice used were overweight. article
Ironically, given the Western diet, even if that is 'all' CR is, it may still be a good idea and life-extending.
Discussed here; timtyler's aware of such results and believes the evidence still points towards CR (which is also my opinion).
In sensible CR experiments (which date back to the 1950s) the control mice are calorie restricted too, precisely in order to rule this possibility out.
What about the Okinawans?
What about them? They eat more and differently these days, and accordingly, Okinawa's life expectancy has fallen.
I was thinking about the pre-WWII Okinawans. Anyway, isn't what you mention further evidence that CR works, even below the not-morbidly-obese line?
It could be, yes. One question I have here is what is 'morbidly obese'? Is it like IQ, where it's essentially a relative ranking (the top fifth is the fattest and defined as morbidly obese), or do we have a clear bright line from biology where a certain weight is the crossing point between good and bad? If it is the former, then for all we know, Okinawans who were eating their fill were still above the bright line even though they look thin and fit from a contemporary American viewpoint.