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timtyler comments on What is the evidence in favor of paleo? - Less Wrong
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I've yet to see any evidence on the effects of calorie restriction on humans. Mice are quite different from us, and all evidence on calorie restriction I've seen was done on mice.
Also, there is no just how long you live, but also life quality. We know the brain is a massive consumer of calories. We know that when people are even in light hypoglycemia, their reflexes and cognitive abilities go down. I never saw any study on the effects of calorie restriction to attention, reflexes and cognitive abilities.
Some human research is listed here.
There are plenty of studies on that - e.g. start here.