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army1987 comments on What is the evidence in favor of paleo? - Less Wrong
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When I ask this question I am usually referred to Gary Taubes. Also see Wikipedia. I don't have time to evaluate the evidence, but I'm pretty skeptical of nutrition science in general.
Edit: Eliezer has spent a few years doing the only thing you can do: try a bunch of diets on yourself and measure the results.
Well, in my case I've found that The Hacker's Diet pretty much works for me: the number of calories I get seems to be way more important than where I get them from (provided I get them from something reasonable, as opposed to 2000 kcal's worth of Coke per day or something like that).