Pablo_Stafforini comments on What is the evidence in favor of paleo? - Less Wrong
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When I ask this question I am usually referred to Gary Taubes. Also see Wikipedia. I don't have time to evaluate the evidence, but I'm pretty skeptical of nutrition science in general.
Edit: Eliezer has spent a few years doing the only thing you can do: try a bunch of diets on yourself and measure the results.
Michael Rae--Aubrey de Grey's co-author and the most knowledgeable person about matters of nutrition and supplementation that I know--doesn't have a high pinion of Gary Taubes. Most of his remarks are spread over several messages on the Calorie Restriction Society mailing list; here's a representative sample: