RichardKennaway comments on What is the evidence in favor of paleo? - Less Wrong

13 Post author: jsteinhardt 27 August 2012 07:07AM

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Comment author: Eliezer_Yudkowsky 28 August 2012 03:53:05AM 12 points [-]

Obviously, the reason I tried and am trying multiple diets is that the experimental result is always that nothing actually works. Except that the Shangri-La diet worked for twenty pounds and then mysteriously stopped doing anything (i.e., abrupt cessation of the diet did not result in any significant change in weight trends) and Seth Roberts couldn't get it working again. Paleo was among the diets tried, and it didn't result in any weight loss or other detectable differences. Non-US-approved, powerful, dangerous drugs like clenbuterol, which are supposed to cause weight loss on the order of a pound a day, produced standard side effects but no weight loss in me.

I figure that metabolisms vary at least 10% as much as minds, which is a HUGE amount of variance. It actually points up something I may post about at some point, which is that statistical science itself is often a dead end - you can publish paper after paper after paper about effects that show up in 60% of the population - but you don't know what separates the 60% from the 40% - and still have no real grasp on the phenomenon and no real ability to manipulate it.

Comment author: RichardKennaway 29 August 2012 08:02:44PM *  1 point [-]

I figure that metabolisms vary at least 10% as much as minds

That may be understating it. Have you come across the book "Biochemical Individuality"? First published in 1956, it catalogues the at times surprisingly large amount of variation among healthy individuals of even such gross physiology as the relative sizes and positioning of the organs. It appears to have been rediscovered in the 90s, but primarily by the less scientific end of the nutrition advice industry. I do not know if there has yet been any reliable work done on the implications of individual uniqueness for, well, just about the whole of medicine, nutrition, and the life and social sciences in general.