It looks like I wrote the grandparent comment over two years ago and I am still primarily using Evernote and Nozbe. Evernote is invaluable for its ability to capture practically any form of information very quickly and then search it later. I can also intersperse "capture" items like reminders with "work" items like drafts of writing.

Nozbe is a fully functional GTD application and it's the backbone of how I manage my tasks.

Theoretically org-mode is great because it combines capture with workspace, but in practice I always found it impossible to smoothly transfer between those two functions.