The problem is that we don't know how influential the blind spot is. It could just fade away after a couple minutes and a "hey, wait a minute..." But assuming it sticks:
If I were a car salesmen, I would have potential customers tell me their ideal car and then I would tell them what I want their ideal car to be as though I were simply restating what they just said.
If I were a politician, I would target identities (e.g., latino, pro-life, low taxes, ect) rather than individuals because identities are made of choices and they're easier to target than individuals. The identity makes a choice and then you assume the identity chose you. E.g., "President Obama has all but said that I'm instigating "class warfare," or that I don't care about business owners, or that I want to redistribute wealth. Well, Mr. Obama, I am fighting with and for the 99%; the middle class; the inner city neighborhoods that your administration has forgotten; Latinos; African-Americans. We all have had enough of the Democrats decades long deafness towards our voice. Vote Romney." Basically, you take the opposition's reasons for not voting for you and then assume those reasons are for the opposition, and you run the ads in the areas you want to affect.
Change blindness is the phenomenon whereby people fail to notice changes in scenery and whatnot if they're not directed to pay attention to it. There are countless videos online demonstrating this effect (one of my favorites here, by Richard Wiseman).
One of the most audacious and famous experiments is known informally as "the door study": an experimenter asks a passerby for directions, but is interrupted by a pair of construction workers carrying an unhinged door, concealing another person whom replaces the experimenter as the door passes. Incredibly, the person giving directions rarely notices they are now talking to a completely different person. This effect was reproduced by Derren Brown on British TV (here's an amateur re-enactment).
Subsequently a pair of Swedish researchers familiar with some sleight-of-hand magic conceived a new twist on this line of research, arguably even more audacious: have participants make a choice and quietly swap that choice with something else. People not only fail to notice the change, but confabulate reasons why they had preferred the counterfeit choice (video here). They called their new paradigm "Choice Blindness".
Just recently the same Swedish researchers published a new study that is even more shocking. Rather than demonstrating choice blindness by having participants choose between two photographs, they demonstrated the same effect with moral propositions. Participants completed a survey asking them to agree or disagree with statements such as "large scale governmental surveillance of e-mail and Internet traffic ought to be forbidden as a means to combat international crime and terrorism". When they reviewed their copy of the survey their responses had been covertly changed, but 69% failed to notice at least one of two changes, and when asked to explain their answers 53% argued in favor of what they falsely believed was their original choice, when they had previously indicated the opposite moral position (study here, video here).