I don't have good data on the subject, and I'm not well-calibrated. But my expectation of the rate of severe errors, made by well-meaning people in a complex endeavor, is for at least 1% retractions (3.5 orders of magnitude above the current 0.0017%). That would still be less than one lifetime retraction per scientist on average.
And another thought: if scientists are really so thorough as to achieve a very low rate of major errors, they are probably overspending. It would be more efficient (fewer false negatives in self-vetting and less time spent self-vetting) to be bolder in publishing and rely more on vetting and reproduction by others.
From Gene Expression by Razib Khan who some of you may also know from the old gnxp site or perhaps from his BHTV debate with Eliezer.
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