If it were me, I'd split your list after reductionism into a separate ebook. Everything that's controversial or hackles-raising is in the later sequences. A (shorter) book consisting solely of the sequences on cognitive biases, rationalism, and reductionism could be much more a piece of content somebody without previous rationalist intentions can pick up and take something valuable away from. The later sequences have their merits, but they are absolutely counterproductive to raising the sanity waterline in this case. They'll label your book as kooky and weird, and they don't, in themselves, improve their readers enough to justify the expense. People interested in the other stuff can get the companion volume.
You could label the pared down volume something self helpey like 'Thinking Better: The Righter, Smarter You." For goodness sake, don't have the word 'sequences' in the title. That doesn't mean anything to anyone not already from LW, and it won't help people figure out what it's about.
EDIT: Other title suggestions - really just throwing stuff at the wall here
Rationality: Art and Practice
The Rational You
The Art of Human Rationality
Black Belt Bayesian: Building a Better Brain
The Science of Winning: Human Rationality and You
Science of Winning: The Art and Practice of Human Rationality (I quite like this one)
Black Belt Bayesian: Building a Better Brain
That one is taken.
As you may have heard, the Singularity Institute is in the process of creating an official ebook version of The Sequences (specifically, Eliezer's Major Sequences written between 2006 and 2009).
Now is an opportune time to make any alterations to the contents of the Sequences. We're looking for suggestions about:
Put separate suggestions in separate comments so that specific changes can be discussed. All suggestions will be reviewed, with final changes made by Eliezer. Next thing you know, you'll be sipping a hot mocha in your favorite chair while reading about Death Spirals on your handy e-reader.
The Sequences that will be present in the ebook: