If it were me, I'd split your list after reductionism into a separate ebook. Everything that's controversial or hackles-raising is in the later sequences. A (shorter) book consisting solely of the sequences on cognitive biases, rationalism, and reductionism could be much more a piece of content somebody without previous rationalist intentions can pick up and take something valuable away from. The later sequences have their merits, but they are absolutely counterproductive to raising the sanity waterline in this case. They'll label your book as kooky and weird, and they don't, in themselves, improve their readers enough to justify the expense. People interested in the other stuff can get the companion volume.

You could label the pared down volume something self helpey like 'Thinking Better: The Righter, Smarter You." For goodness sake, don't have the word 'sequences' in the title. That doesn't mean anything to anyone not already from LW, and it won't help people figure out what it's about.

EDIT: Other title suggestions - really just throwing stuff at the wall here

• Rationality: Art and Practice

• The Rational You

• The Art of Human Rationality

• ~~Black Belt Bayesian: Building a Better Brain~~

• The Science of Winning: Human Rationality and You

• Science of Winning: The Art and Practice of Human Rationality (I quite like this one)