Mitchell_Porter comments on Abandoning Cached Selves to Re-Write My Source Code Partially, I've Become Unstable - Less Wrong
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The guy is dedicated to cryonics and "existential risk", among other things. Those are extremely uncommon interests, so just in terms of cognitive content, he is clearly in a minority.
On the other hand, it could be a bit ostentatious to claim to be a "cognitive minority" just because you believe uncommon things. To me, "cognitive minority" suggests that your process of thought is unusual, not just its contents. (Although the two aren't completely separate; unusual cognitive content can have consequences for process, if you regularly end up arriving at unusual conclusions because of your unusual premises.)
Now maybe the point of your religious/transhumanist analogy is that the "burnout of a transhumanist altruist" is not as unique as it sounds; that it's just a secular manifestation of a weariness with saving the world and spreading the good news, that might affect anyone with utopian or transcendent aspirations that society refuses to support. I will concede this much, that the same feeling might be felt by an exhausted Christian evangelist, or by an exhausted Marxist evangelist.
But the basis of the specific hopes does make a difference. The Christian hope is based on emotion, coincidence, a sense that the soul is distinct from the body, rumors of miracles, and faith in authority. The Marxist hope is based on the excitement of revolution, belief in progress, the theory of history as class struggle, and optimism about the nature of life in high-tech collectivist societies. The transhumanist hope is based on science and technology. In its individual flavors it may be naively optimistic, naive about politics, wrong about human psychology, wrong about specific scenarios. But the progress of science and technology is giving us a lot of reason to think that something like rejuvenation is materially possible. I can't say the same for the Second Coming of Christ, or the moneyless harmony of the Venus Project.
That's what transhumanists like to tell themselves, much like Marxists talking about "scientific socialism", or some brands of Christians with their "creation science" and "intelligent design".
Transhumanists are the spiritual grandchildren of the sixteenth century (edited) alchemists who tried to make the Philosopher's stone and the Homunculus. They can dress it with scientific-sounding language and speculative technology, but the irrational cognitive processes that underlay the formation and maintenance of such beliefs are the same of other religious or religious-like belief systems.
Sure, but that falls in the scope of medical science: My grandma had walking difficulties because her knee had worn out with age. So her knee was replaced by an artificial one, and now she walks like when she was younger. Is she a transhuman cyborg?
When a medical procedure of proven effectiveness becomes available, it is applied without much fuss. This has nothing to do with freezing corpses and dreaming of brain uploads and godlike AIs.
We have space travel, robots, instant communication with the other side of the world, instant access to most art and most writing ever produced, weapons based on the reactions that power the stars, systems of wires that transmit an invisible energy that makes our mechanical slaves operate, face transplants, X-rays, cloning... and you think those people were irrational?