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Luke_A_Somers comments on Beyond Bayesians and Frequentists - Less Wrong
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Every biology paper released based on a 5% P-value threshold without regard to the underlying plausibility of the connection. There are many effects where I wouldn't take a 0.1% P-value to mean anything (see: kerfluffle over superluminal neutrinos), and some where I'd take a 10% P-value as a weak but notable degree of confirmation.