gwern comments on Open Thread, November 1-15, 2012 - Less Wrong
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FWIW, my line of thinking there was 'Grognor says his aggression has disappeared; testosterone is popularly associated with aggression (even though my old post on testosterone quotes some material suggesting this is partially due to cultural expectations), so that can't be it, but the opposite of testosterone is estrogen'; a line later, 'in my search for funnier and more exotic explanations for Grognor being less misanthropic than usual, why would Grognor be taking estrogen? Oh, transexuals.'