Is the idea that some group has confounded the knowledge base used to maintain said simulation for the express purpose of bestowing superpowers upon their progeny or all of future humanity?

If that's what you're going for, then I'd refer to that group as either crazy or a bunch of really fun people that were having a laugh, knowing the probability of their efforts paying off to be extremely slim, who coincidentally were absolutely spot on.

I imagine the most effective approach would be propagating reports of small, odd phenomena that hint at the universe having (had) features not (yet) identified by the laws of physics. Then the descendants could exploit the resulting uncertainty of the simulation through heroic journeys of super-power discovery. The descendants would either be protagonists, or all of humanity; I think the latter more ambitious but also permissive of a larger scope and greater intrigue than the former.