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MugaSofer comments on LW Women- Minimizing the Inferential Distance - Less Wrong
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... because you don't, as a rule, choose your own neurophysiology. Certain structures in transsexuals' brains are closer to the form they take in cisgendered members of the sex they identify with than the sex they appear to be.
Become a taxi driver and grow your hippocampus. The boundary between what you can change and what you can't is not as clear as you seem to think.
Do we know what these structures do?
As I have said elsewhere, there is a sliding scale involved. This is decidedly towards the "unchosen" end, and considering that transsexuals report having changed their lifestyle as a result of preexisting problems, it seems reasonable to call this one for the "nature" side.
Besides this? No.
You have some control over it. Everything you do and every thought you have affects your neurophysiology. How much control you have over it is an interesting question, which can't be answered simply by pointing to differences on brain scans.
There's a sliding scale. At one end, we have things like frontal lobes. At the other, we have imagination. This is the kind of structure that doesn't alter without external stimuli, and even then it's bloody hard.