each of us can strive to be the best he can be, to play as best he can the hand he's been dealt

But look, he demands that we accept it as a tolerable state of affairs! Eliezer says the opposite - yes, no particular person is to blame, but things are still horrible; we're still living in a nightmare. To borrow from left-wing jargon again, I want a right to negativity here, a forceful statement that the default/normal/natural condition is awful, even with no-one to blame, and that there is an ethical imperative to ameliorate it.

Derbyshire's article should have begun with "oughts", his "is" statements might be true but they're insufficient for humans. The fact that you being born e.g. black and in the slums and now you're likely fucked and maladapted is no-one else's fault does not mean that you are not entitled to scream, to express anguish. And dude, there's a lot of anguish!