In the same vein of pharmaceutical solutions...

I used to, as a college student, have a terrible time getting to bed. I had 8 AM classes, and so I really needed to go to bed at a reasonable time like midnight (and not 2 or 3 AM); and in the morning I would regret tremendously staying up late. A classic case of akrasia - I could probably have even quantified it all in terms of grades.

My solution was to realize that the problem was that at any moment I was enjoying whatever more than I needed the sleep. I needed some way to induce a 'false' sleepiness. So I looked up the options and found melatonin. 3mg of melatonin would practically club me into sleepiness after 30 minutes - so it solved the issue of not wanting to go to bed.

Of course, this caused another problem: taking the melatonin at the right time! But this turned out to be much less of an issue, perhaps because taking a pill is so much easier than winding up for the night and going to bed.

EDIT: see my full length post on melatonin: http://lesswrong.com/lw/1lt/case_study_melatonin/