The man-made object responsible for the most deaths worldwide is the tobacco cigarette. It isn't even close.
Tobacco kills 443,000 Americans a year and 5 million people a year worldwide. This is more than the total number of people killed by cars and firearms combined. Cars kill about 32,000 Americans each year and 1.3 million people worldwide, while firearms kill about 32,000 Americans each year and "several hundred thousand" people worldwide.
100 million people were killed by tobacco in the 20th century. This is more than the death toll from World War 1 (17 million) and World War 2 (50 to 70 million) combined.
From a strictly utilitarian perspective, would there be anything to be gained by, say, starting a campaign of assassination against executives of tobacco companies?
Well, it would be unlikely to convince people not to smoke. It would create a kooky outgroup faction, the Violent Anti-Smokers, that people would be afraid to be associated with, so people would become uncomfortable with being too vocally anti-smoking lest they be mistaken for one of Them. No such campaign is likely to be effective enough to make people unwilling to become the executive of a tobacco company to the point that positions aren't filled, they'd just ramp up security.
Also, deaths-caused isn't really the best metric for toll on human society. Cigarettes rarely do anyone in at thirty, while car accidents don't discriminate. Adjusting to life-years-lost would be a step in the right direction.
Yep.