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Douglas_Knight comments on Open Thread, January 16-31, 2013 - Less Wrong
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Ioannidis suggests that better journals produce less accurate research. A separate effect is that generalist journals are spread too a thin and can't competently referee. (eg, one editor can be highly biased towards his friends without the other editors being able to tell)
The statistician Andrew Gelman likes calling Science and Nature "the tabloids" because they attract the sort of research which is most exciting (and hence the most unexpected and most likely to be false).