For instance, while people with delusions may clearly have poor models of the world, some research indicates that clinically depressed people may have lower levels of particular cognitive biases.

Huh, I hadn't heard that.

Clearly, reality is so Lovecraftian that any unbiased agent will immediately realize self-destruction is optimal. Evolution equipped us with our suite of biases to defend against this. The Great Filter is caused by bootstrapping superintelligences being compassionate enough to take their compatriots with them. And so on.

Now that's a Cosmic Horror story I'd read ;)