Qiaochu_Yuan comments on MetaMed: Evidence-Based Healthcare - Less Wrong
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Some people (myself included) use "spam" to refer to any kind of advertising in a public setting, e.g. you might preface an email sent out to multiple mailing lists as "sorry for the spam, guys, but..." even if it's a valuable and high-quality email. The connotation, to me, is mildly self-deprecating rather than strictly negative.