Kawoomba comments on MetaMed: Evidence-Based Healthcare - Less Wrong

83 Post author: Eliezer_Yudkowsky 05 March 2013 01:16PM

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Comment author: Kawoomba 05 March 2013 06:01:23PM 3 points [-]

Of note, 23andme tests for genetically determined warfarin tolerance. I can copypasta their references on demand.

Comment author: J_C 06 March 2013 12:43:08PM 5 points [-]

This is actually not relevant as warfarin dosage is determined by regular testing and dose adjustment. Your inborn metabolic rate is a very small effect compared to, for example, dietary preferences. (for those who are unfamiliar with the agent, warfarin antagonises the effects of vitamin K and so must be adjusted against dietary intake)

Unfortunately there are many people in the health sector offering tests that, whilst factually correct, are irrelevant to a patient's care.

Comment author: Kawoomba 06 March 2013 02:03:45PM 3 points [-]

Someone tell the NHS, which is sponsoring a large trial to explore just that question.

The influence of the genotype varies from "typical sensitivity" to "may require greatly decreased warfarin dose". A range that is all but irrelevant, regular testing or no (think for example of the initial dosage).