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timtyler comments on SENS and Givewell: Conversation between Holden Karnofsky and Aubrey de Grey - Less Wrong
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Holden seems sceptical, which seems appropriate to me. FWIW, I am not clear what function is being optimised in cases where where SENS gets recommended for funding. I figure that work aiming at prolonging lives is probably already over funded by the old-sick-friends-and-relatives phenomenon.
In the US (I'm not sure about in other countries), medical spending is skewed heavily towards people who are already very sick and often dying, while SENS is focused on delaying the onset of that state. Even if work on prolonging lives is over-funded, the funding that goes into it is likely being directed primarily to much less efficient ways of doing it.
Existing expenditure probably isn't effectively directed. However, SENS doesn't seem to be very much better. It's oriented towards biomedical gerontology. It seems pretty obvious that the way to produce potentially long-lived minds is to create them in a digital substrate - so that they can be copied and backed up. SENS seems to be pretty irrelevant to that project.