I've read that introverts in general deal better with sleep deprivation than extroverts. I don't know just how resilient against sleep deprivation their cast is likely to be, but I'm personally resistant enough that I doubt sleep deprivation would do a great deal to assist in engineering drama. In college, none of my peers were able to notice the difference when I went over 130 hours without sleep, and I doubt the show would be able to engineer deprivation levels approaching that without courting allegations of abuse.