Why not something catchy? The sequences often had extremely catchy titles (eg "An Alien God"). "Becoming Less Wrong" is pretty good, but it doesn't have enough pizzazz. How'sabout something like:

• "If you're reading this, Phase One of my master plan is already complete" (yes, stolen from a T-shirt, but rather appropriate) or
• "The world is mad, you don't have to be"

or some variety of the 'rationality is applied winning' meme:

• "On Winning"
• "Winning - Theory and Practice"

Maybe a take on defeating Azathoth?

• "Kill a God - Become an Agent"
• "Wresting Control of Yourself from Evolution's Grasp"

At any rate, the Memetic Hazard sign should be somewhere on the cover. :)