I think that the simulation hypothesis does not permit any evidence for or against that does not violate the laws of physics. There's no way to distinguish between being in a real universe, a discrete simulation of a continuous universe, a discrete simulation of a discrete universe, or a continuous simulation of either a discrete or continuous universe with limited measuring tools.

If the laws of physics starting changing in dramatically interesting ways, I might see that as evidence of simulation... and now I need to reevaluate the evidence about cold fusion in that light...