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DysgraphicProgrammer comments on Post ridiculous munchkin ideas! - Less Wrong
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He actually spent the first two months on a Soylent-only diet, and only recently added social eating. I think he said something in his three month blog post about a week he spent eating normal food, and he ended up feeling way crappier.
That was also a week he spent travelling. Sleeping away from home, long plane/car rides, irregular schedule, and all the other attendant discomforts are quite enough to throw me off my game, even without dietary shifts.
Could also be a temporary effect. Your gut flora adjusts to what you're eating, and a sudden shift in composition can cause digestive distress.