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This reminds me of the story of Robert Edgar, who created the DNA and protein sequence alignment program MUSCLE.
He got a PhD in physics, but considers that a mistake. He did his bioinformatics work after selling a company and having free time. The bioinformatics work was notable enough that it's how I know of him.
His blog post, from which I learned this story: https://thewinnower.com/discussions/an-unemployed-gentleman-scholar