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gwern comments on [LINK] Possible Unrepresentative Subjects in Studies of Medical Interventions - Less Wrong
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Other issues with the commercial running of RCTs can include patients enrolling in multiple trials at once (apparently some people even treat it as a very low-paid career), lying about symptoms to not get kicked out, etc. GIGO.
Honestly, what I found more interesting was the difficulty in generalizing from the RCT population to the treatment population.
Does intervention X work for homeless people with problem Y? Who knows, they were excluded from the RCT. But most of the population with Y is homeless.