DanArmak comments on Using Evolution for Marriage or Sex - Less Wrong
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The biggest biological danger of casual sex was (to women) unwanted pregnancy. It's now almost gone thanks to modern contraception.
STDs certainly exist, but they too have become rarer. Syphilis used to cause a lot of mortality and disability, and was mostly (not entirely) defeated by antibiotics. And with modern health care and social safety nets, if you do get sick, your outlook is much better than even a century ago.