Another possibility is that whoever is running the simulation is both computationally very rich and not especially interested in humans, they're interested in the sub-atomic flux or something. We're just a side-effect.
In that case, you've lost the anthropic argument entirely, and whether or not we're a simulation relies on your probability distributions over possible simulating agents, which is... weird.
Jonathan Birch recently published an interesting critique of Bostrom's simulation argument. Here's the abstract:
The paper is behind a paywall, but I have uploaded it to my shared Dropbox folder, here.
EDIT: I emailed the author and am glad to see that he's decided to participate in the discussion below.