In that case, you've lost the anthropic argument entirely, and whether or not we're a simulation relies on your probability distributions over possible simulating agents, which is... weird.
How did I lose the anthropic argument? We're still only going to know about the sort of universe we're living in.
Jonathan Birch recently published an interesting critique of Bostrom's simulation argument. Here's the abstract:
The paper is behind a paywall, but I have uploaded it to my shared Dropbox folder, here.
EDIT: I emailed the author and am glad to see that he's decided to participate in the discussion below.