TrE comments on Changing Systems is Different than Running Controlled Experiments - Don’t Choose How to Run Your Country That Way! - Less Wrong
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To connect this to the problem of (cost) function minimization, which is important e.g. in machine learning, changing a single variable at a time is even worse than gradient descent, which is a common method there. Not only do you only look in the immediate neighborhood, you also only look along a single axis at a time. It's no wonder that you don't find a local minimum this way!