twiffy comments on Many Weak Arguments vs. One Relatively Strong Argument - Less Wrong
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I don't have much more evidence, but I think that it's significant that:
Physicists developed quantum field theory in the 1950's, and that it still hasn't been made mathematically rigorous, despite the fact that, e.g., Richard Borcherds appears to have spent 15 years (!!) trying.
The mathematicians who I know who have studied quantum field theory have indicated that they don't understand how physicists came up with the methods that they did.
These suggest that the physicists who invented this theory reasoned in a very different way from how mathematiicans usually do.
As a tangent, I think it's relatively clear both how physicists tend to think differently from mathematicians, and how they came up with path-integration-like techniques in QFT. In both math and physics, researchers will come up with an idea based on intuition, and then verify the idea appropriately. In math the correct notion of verification is proof; in physics it's experimentation (with proof an acceptable second). This method of verification has a cognitive feedback loop to how the researcher's intuition works. In particular physicists have intuition that's based on physical intuition and (generally) a thoroughly imprecise understanding of math, so that from this perspective, using integral-like techniques without any established mathematical underpinnings is intuitively completely plausible. Mathematicians would shirk away from this almost immediately as their intuition would hit the brick wall of "no theoretical foundation".