That seems uncharitable. I can see there being issues that go largely unaddressed by most of the major identity groups out there but which nonetheless end up looking important if we view the political landscape through a different set of filters as OP suggested, and those shouldn't run afoul of any of the pitfalls I brought up. They might be harder to find than OP's implying, though; political factions might be slow-moving and broadly irrational, but they're not entirely blind to potential unexploited planks.

The War on Drugs probably isn't one: opposition to it is near-ubiquitous among the LW commentariat, but I think that's because the groups most strongly supportive of it are badly represented around here. Judicial reform might be one, although I'd need to know which judicial reforms.