army1987 comments on Initial Thoughts on Personally Finding a High-Impact Career - Less Wrong
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Not doing something irreversible to myself while I'm still in my twenties unless I'm dead sure about it sounds like a very good heuristic to me. See also rabbis being supposed (IIUC) to dissuade prospective converts to Judaism, stuff people do before getting married, etc.
(RISUG will likely make that moot.)