WHOAH, this is amazing! Thank you for the summary and link.
I'm curious why you say caution is warranted given that supplemental B12 and folate are highly innocuous with doses 10x the RDA still not showing any toxicity.
Caution is warranted for a few reasons:
I've been told that the liver uses methylfolate for detoxification. If you take too much too soon, or ramp up too quickly, you will end up really feeling like hell because of the detoxification process. This may be more of a problem for people who have toxins built up in their system due to inefficient detoxification.
I've been told that methylfolate can increase your blood pressure. Your doctor may need to be monitoring this.
I've been told that if you do need all three of methylfolate, methylcobalamin and a h
P/S/A: There are single sentences which can create life-changing amounts of difference.