Sure, but it isn't at all obvious that humans are substantially different either in terms predictability. For purposes of this conversation, that's the standard.
I think it depends on your threshold of "substantial." A human brain responds in a complex an (probably) noisy fashion to inputs from the rest of the world. That I might choose to flip coins and choose actions based on the outcome is part of the operation of my future thoughts and actions. In my case, I would choose random numbers based on complex and noisy physical operations. For example, the 4th decimal place of a voltmeter reading the voltage across a hot resistor, and to make it fun, I would take the 4th place at exactly 15 seconds after...
Excuse the horrible terribad pun...
An evil Omega has locked you in a box. Inside, there is a bomb and a button. Omega informs you that in an hour the bomb will explode, unless you do the opposite of what Omega predicted you will do. Namely, press the button if it predicted you won't or vice versa. In that case, the bomb won't explode and the box will open, letting you free.
Your actions?
PS. You have no chance to survive make your time.
PPS. Quick! Omega predicted that in exactly 5 second from now, you will blink. Your actions?
PPPS. Omega vs. Quantum Weather Butterfly. The battle of the Eon!