Jiro comments on Evidential Decision Theory, Selection Bias, and Reference Classes - Less Wrong
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Having a physical condition affect whether one smokes, while also posing a problem which implies that you can choose whether to smoke, suggests a variation of the problem: there's a brain lesion which increases your lifespan, but makes you incapable of computing conditional probabilities (plus some other effect that is enough for there to be a genuine question of how you should act). How should you behave in this version?