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gwern comments on "Stupid" questions thread - Less Wrong
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Is it possible to train yourself the big five in personality traits? Specifically, conscientiousness seems to be correlated with a lot of positive outcomes, so a way of actively promoting it would seem a very useful trick to learn.
Not that I know of. The only current candidate is to take psilocybin to increase Openness, but the effect is relatively small, it hasn't been generalized outside the population of "people who would sign up to take psychedelics", and hasn't been replicated at all AFAIK (and for obvious reasons, there may never be a replication). People speculate that dopaminergic drugs like the amphetamines may be equivalent to an increase in Conscientiousness, but who knows?